Linked Life Data

19569223

Source:http://linkedlifedata.com/resource/pubmed/id/19569223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-25
pubmed:abstractText
A composite polymeric material, poly(styrene-block-isobutylene-block-styrene) (SIBS) with an embedded reinforcement polyethylene terephthalate (PET) fabric, is undergoing investigation for potential use in a novel heart valve. The purpose of this study was to develop and implement a small animal model to assess the biocompatibility of composite samples in a cardiovascular tissue and blood-contacting environment. Composite samples were manufactured using dip coating and solvent casting with two coating thicknesses (25 and 50 microm). A novel rat abdominal aorta model was developed to test the dip-coated samples in a similar pulsatile flow condition to its intended use, and both dip-coated and solvent-cast samples were tested using a rat subcutaneous model. Tissue response, defined by degree of cellular infiltration and encapsulation, was minimized when a smooth coating of SIBS shielded the PET fabric from exposure to blood and tissue, and the degree of tissue response was directly correlated with the degree of surface roughness. Surface modification using phospholipid further reduces the tissue response. We have demonstrated the applicability of using a novel rat abdominal aorta model for biocompatibility assessment of polymeric materials that will be used in cardiovascular implants. For the purpose of this study, our results indicate that solvent casting with a 25-microm SIBS coating thickness will provide optimal biocompatibility for the SIBS valve.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1552-4965
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Wiley Periodicals, Inc.
pubmed:issnType
Electronic
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
442-53
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
A novel small animal model for biocompatibility assessment of polymeric materials for use in prosthetic heart valves.
pubmed:affiliation
Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, EC 2610, Miami, Florida 33174, USA.
pubmed:publicationType
Journal Article, Evaluation Studies, Research Support, N.I.H., Extramural