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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-1-2
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pubmed:abstractText |
486 patients followed in four French hemophilia centres were tested for antibody to hepatitis C virus C100-3 recombinant protein. On samples collected in 1989, the overall incidence of anti-C 100-3 positivity was 66%. None of the 27 patients only exposed to solvent-detergent treated factor VIII or IX concentrates had C 100-3 antibodies. There was no difference according to the type of hemophilia nor to its severity. Serological follow-up from 1985 to 1989 was carried out on 51 patients. Two third of the C-100 3 paradoxically seronegative patients in 1989 were in fact positive for these antibodies within the last 5 years. They have lost their HCV antibodies as seen with the presently available C 100-3 test. Actually, as the virus has been already present at least for the last 10 years, (on 51 samples collected in 1979, the incidence of C-100-3 positivity was 78%), all treated patients may well have been in contact with HCV.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:author |
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1956764-Adolescent,
pubmed-meshheading:1956764-Adult,
pubmed-meshheading:1956764-Aged,
pubmed-meshheading:1956764-Aged, 80 and over,
pubmed-meshheading:1956764-Alanine Transaminase,
pubmed-meshheading:1956764-Child,
pubmed-meshheading:1956764-Child, Preschool,
pubmed-meshheading:1956764-Cohort Studies,
pubmed-meshheading:1956764-Factor IX,
pubmed-meshheading:1956764-Factor VIII,
pubmed-meshheading:1956764-France,
pubmed-meshheading:1956764-HIV Infections,
pubmed-meshheading:1956764-HIV Seroprevalence,
pubmed-meshheading:1956764-Hemophilia A,
pubmed-meshheading:1956764-Hemophilia B,
pubmed-meshheading:1956764-Hepatitis Antibodies,
pubmed-meshheading:1956764-Hepatitis B,
pubmed-meshheading:1956764-Hepatitis C,
pubmed-meshheading:1956764-Hepatitis C Antibodies,
pubmed-meshheading:1956764-Humans,
pubmed-meshheading:1956764-Incidence,
pubmed-meshheading:1956764-Infant,
pubmed-meshheading:1956764-Middle Aged,
pubmed-meshheading:1956764-Prevalence
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pubmed:year |
1991
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pubmed:articleTitle |
Antibody to hepatitis C (anti C 100-3) in French hemophiliacs.
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pubmed:affiliation |
Centre d'Hématologie et de Transfusion Sanguine de Versailles, Le Chesnay, France.
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pubmed:publicationType |
Journal Article
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