|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-9-7
|
|
pubmed:abstractText |
The chronic use of organic nitrates is limited by serious side effects including oxidative stress, nitrate tolerance and/or endothelial dysfunction. The side effects and potency of nitroglycerine depend on mitochondrial aldehyde dehydrogenase (ALDH-2). We sought to determine whether this concept can be extended to a new class of organic nitrates with amino moieties (aminoalkyl nitrates).
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1476-5381
|
|
pubmed:author |
pubmed-author:DaiberAA,
pubmed-author:KönigAA,
pubmed-author:KawamotoTT,
pubmed-author:LangeKK,
pubmed-author:LehmannJJ,
pubmed-author:MünzelTT,
pubmed-author:OelzeMM,
pubmed-author:RoeglerCC,
pubmed-author:SchuhmacherSS,
pubmed-author:SchulzEE,
pubmed-author:SydorKK,
pubmed-author:WenzelPP
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
158
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
510-20
|
|
pubmed:dateRevised |
2010-9-2
|
|
pubmed:meshHeading |
pubmed-meshheading:19563531-Acetylcholine,
pubmed-meshheading:19563531-Aldehyde Dehydrogenase,
pubmed-meshheading:19563531-Animals,
pubmed-meshheading:19563531-Drug Tolerance,
pubmed-meshheading:19563531-Ethanolamines,
pubmed-meshheading:19563531-Male,
pubmed-meshheading:19563531-Mice,
pubmed-meshheading:19563531-Mice, Inbred C57BL,
pubmed-meshheading:19563531-Mice, Knockout,
pubmed-meshheading:19563531-Mitochondria,
pubmed-meshheading:19563531-Nitrates,
pubmed-meshheading:19563531-Nitroglycerin,
pubmed-meshheading:19563531-Oxidative Stress,
pubmed-meshheading:19563531-Vasodilation
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena.
|
|
pubmed:affiliation |
II. Medizinische Klinik, Labor für Molekulare Kardiologie, Johannes-Gutenberg-Universität, Mainz, Germany.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
