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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2009-7-14
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pubmed:abstractText |
We reported recently the Structure-Activity Relationship (SAR) of a class of CXCL8 allosteric modulators. They invariably share a 2-arylpropionic moiety so far considered a key structural determinant of the biological activity. We show the results of recent SAR studies on a novel series of phenylacetic derivatives supported by a combined approach of mutagenesis experiments and conformational analysis. The results suggest novel insights on the fine role of the propionic/acetic chain in the modulation of CXCL8 receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AllegrettiMarcelloM,
pubmed-author:AraminiAndreaA,
pubmed-author:AschiMassimilianoM,
pubmed-author:BertiniRiccardoR,
pubmed-author:BizzarriCinziaC,
pubmed-author:CestaMaria CandidaMC,
pubmed-author:CrucianelliMarcelloM,
pubmed-author:Di BitondoRosaR,
pubmed-author:Di GiacintoClaudiaC,
pubmed-author:GloaguenIsabelleI,
pubmed-author:MoriconiAlessioA,
pubmed-author:SabloneManolo RoccoMR
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4026-30
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pubmed:meshHeading |
pubmed-meshheading:19560921-Allosteric Regulation,
pubmed-meshheading:19560921-Allosteric Site,
pubmed-meshheading:19560921-Chemistry, Organic,
pubmed-meshheading:19560921-Chemistry, Pharmaceutical,
pubmed-meshheading:19560921-Chemotaxis,
pubmed-meshheading:19560921-Humans,
pubmed-meshheading:19560921-Inhibitory Concentration 50,
pubmed-meshheading:19560921-Models, Chemical,
pubmed-meshheading:19560921-Models, Molecular,
pubmed-meshheading:19560921-Molecular Conformation,
pubmed-meshheading:19560921-Mutagenesis,
pubmed-meshheading:19560921-Mutation,
pubmed-meshheading:19560921-Receptors, Interleukin-8A,
pubmed-meshheading:19560921-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
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pubmed:affiliation |
Research Center, Dompé pha.r.ma s.p.a., via Campo di Pile, 67100, L'Aquila, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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