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rdf:type |
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lifeskim:mentions |
umls-concept:C0038774,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0243072,
umls-concept:C0279516,
umls-concept:C0282563,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C1524075,
umls-concept:C1883254,
umls-concept:C2700400
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pubmed:issue |
15
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pubmed:dateCreated |
2009-7-14
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pubmed:abstractText |
In an effort to find new antibiotics, a novel series of 14-membered macrolides with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains has been synthesized based on commercially available clarithromycin. Chemical transformation of hydroxy group at position C-3 afforded range of ketolides and acylides. Compared to telithromycin, compound 15a demonstrated improved in vitro activity against erythromycin-susceptible and -resistant strains.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4079-83
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pubmed:meshHeading |
pubmed-meshheading:19560350-Anti-Bacterial Agents,
pubmed-meshheading:19560350-Chemistry, Pharmaceutical,
pubmed-meshheading:19560350-Clarithromycin,
pubmed-meshheading:19560350-Drug Design,
pubmed-meshheading:19560350-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:19560350-Erythromycin,
pubmed-meshheading:19560350-Humans,
pubmed-meshheading:19560350-Imidazoles,
pubmed-meshheading:19560350-Ketolides,
pubmed-meshheading:19560350-Macrolides,
pubmed-meshheading:19560350-Microbial Sensitivity Tests,
pubmed-meshheading:19560350-Models, Chemical,
pubmed-meshheading:19560350-Respiratory Tract Infections,
pubmed-meshheading:19560350-Staphylococcus aureus,
pubmed-meshheading:19560350-Streptococcus pneumoniae,
pubmed-meshheading:19560350-Sulfides,
pubmed-meshheading:19560350-Sulfur
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity.
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pubmed:affiliation |
Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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