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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-7-29
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pubmed:abstractText |
Tangier disease (TD), caused by deficiency of ATP-binding cassette transporter A1, is characterized by the absence of high density lipoprotein and the accumulation of cholesteryl esters in many tissues. Recently, it has been reported that ABCA1 is expressed in pancreatic beta cells and mice with specific inactivation of ABCA1 in beta cells showed markedly impaired insulin secretion, suggesting that ABCA1 deficiency may be involved in diabetes. The aim of the current study was to confirm these findings by the oral glucose tolerance test (OGTT) in human subjects with ABCA1 deficiency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1880-3873
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pubmed:author |
pubmed-author:HiranoKen-ichiK,
pubmed-author:InagakiMiwakoM,
pubmed-author:IshigamiMasatoM,
pubmed-author:KawaseRyotaR,
pubmed-author:KosekiMasahiroM,
pubmed-author:KumonYoshitakaY,
pubmed-author:MasudaDaisakuD,
pubmed-author:MatsuuraFumihikoF,
pubmed-author:MatsuyamaAkifumiA,
pubmed-author:Nakagawa-ToyamaYumikoY,
pubmed-author:NakamuraTadashiT,
pubmed-author:NakaokaHajimeH,
pubmed-author:NakataniKazuhiroK,
pubmed-author:NishidaMakotoM,
pubmed-author:OhamaTohruT,
pubmed-author:SakaneNaokiN,
pubmed-author:SandovalJose CJC,
pubmed-author:ShimomuraIichiroI,
pubmed-author:SuehiroTadashiT,
pubmed-author:Tsubakio-YamamotoKazumiK,
pubmed-author:YamashitaShizuyaS,
pubmed-author:Yuasa-KawaseMiyakoM
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
292-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19556721-ATP-Binding Cassette Transporters,
pubmed-meshheading:19556721-Aged,
pubmed-meshheading:19556721-Blood Glucose,
pubmed-meshheading:19556721-Case-Control Studies,
pubmed-meshheading:19556721-Diabetes Mellitus, Type 2,
pubmed-meshheading:19556721-Female,
pubmed-meshheading:19556721-Glucose,
pubmed-meshheading:19556721-Glucose Tolerance Test,
pubmed-meshheading:19556721-Humans,
pubmed-meshheading:19556721-Insulin,
pubmed-meshheading:19556721-Japan,
pubmed-meshheading:19556721-Male,
pubmed-meshheading:19556721-Middle Aged,
pubmed-meshheading:19556721-Mutation,
pubmed-meshheading:19556721-Tangier Disease
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pubmed:year |
2009
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pubmed:articleTitle |
Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. koseki@imed2.med.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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