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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-8-3
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pubmed:abstractText |
We have previously demonstrated that aromatase mRNA is induced in cervical carcinomas compared to normal tissue, suggesting that in situ aromatase expression leading to elevated local estrogen production may contribute to cervical carcinogensis. Our objectives are to examine 1) whether aromatase protein and activity are induced in cervical carcinomas, 2) aromatase expression correlates with disease stage, and 3) inflammatory cytokines (e.g., IL-6 and TNFalpha) may correlate with aromatase expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1095-6859
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-500
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pubmed:meshHeading |
pubmed-meshheading:19555998-Adult,
pubmed-meshheading:19555998-Aged,
pubmed-meshheading:19555998-Aged, 80 and over,
pubmed-meshheading:19555998-Aromatase,
pubmed-meshheading:19555998-Disease Progression,
pubmed-meshheading:19555998-Female,
pubmed-meshheading:19555998-HeLa Cells,
pubmed-meshheading:19555998-Humans,
pubmed-meshheading:19555998-Immunohistochemistry,
pubmed-meshheading:19555998-Interleukin-6,
pubmed-meshheading:19555998-Middle Aged,
pubmed-meshheading:19555998-Neoplasm Staging,
pubmed-meshheading:19555998-Promoter Regions, Genetic,
pubmed-meshheading:19555998-RNA, Messenger,
pubmed-meshheading:19555998-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19555998-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19555998-Uterine Cervical Neoplasms
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pubmed:year |
2009
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pubmed:articleTitle |
Elevated aromatase expression correlates with cervical carcinoma progression.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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