Linked Life Data

19553612

Source:http://linkedlifedata.com/resource/pubmed/id/19553612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-12-3
pubmed:abstractText
Genetics has made significant contributions to the study of glaucoma over the past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing enzyme that is especially expressed in retinal ganglion cells. CYP46A1 and its metabolic product, 24S-hydroxycholesterol, have been linked to neurodegeneration. A single-nucleotide polymorphism (SNP) in the CYP46A1 gene, designated as rs754203 and associated with Alzheimer disease, was evaluated as a genetic risk factor for primary open-angle glaucoma (POAG), as well as plasma 24S-hydroxycholesterol levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1552-5783
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5712-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.
pubmed:affiliation
Eye and Nutrition Research Group, UMR1129 FLAVIC (Flaveur, vision et comportement du consommateur; Flavor, Vision, and Consumer Behavior), INRA (French National Institute for Agricultural Research), Dijon, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't