Source:http://linkedlifedata.com/resource/pubmed/id/19553435
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
25
|
| pubmed:dateCreated |
2009-6-25
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| pubmed:abstractText |
Cognition is regulated across the 24 h sleep-wake cycle by circadian rhythmicity and sleep homeostasis through unknown brain mechanisms. We investigated these mechanisms in a functional magnetic resonance imaging study of executive function using a working memory 3-back task during a normal sleep-wake cycle and during sleep loss. The study population was stratified according to homozygosity for a variable-number (4 or 5) tandem-repeat polymorphism in the coding region of the clock gene PERIOD3. This polymorphism confers vulnerability to sleep loss and circadian misalignment through its effects on sleep homeostasis. In the less-vulnerable genotype, no changes were observed in brain responses during the normal-sleep wake cycle. During sleep loss, these individuals recruited supplemental anterior frontal, temporal and subcortical regions, while executive function was maintained. In contrast, in the vulnerable genotype, activation in a posterior prefrontal area was already reduced when comparing the evening to the morning during a normal sleep-wake cycle. Furthermore, in the morning after a night of sleep loss, widespread reductions in activation in prefrontal, temporal, parietal and occipital areas were observed in this genotype. These differences occurred in the absence of genotype-dependent differences in circadian phase. The data show that dynamic changes in brain responses to an executive task evolve across the sleep-wake and circadian cycles in a regionally specific manner that is determined by a polymorphism which affects sleep homeostasis. The findings support a model of individual differences in executive control, in which the allocation of prefrontal resources is constrained by sleep pressure and circadian phase.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
1529-2401
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
24
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| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7948-56
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:19553435-Adolescent,
pubmed-meshheading:19553435-Adult,
pubmed-meshheading:19553435-Brain,
pubmed-meshheading:19553435-Case-Control Studies,
pubmed-meshheading:19553435-Circadian Rhythm,
pubmed-meshheading:19553435-Cognition,
pubmed-meshheading:19553435-Female,
pubmed-meshheading:19553435-Frontal Lobe,
pubmed-meshheading:19553435-Genotype,
pubmed-meshheading:19553435-Homeostasis,
pubmed-meshheading:19553435-Homozygote,
pubmed-meshheading:19553435-Humans,
pubmed-meshheading:19553435-Magnetic Resonance Imaging,
pubmed-meshheading:19553435-Male,
pubmed-meshheading:19553435-Neuropsychological Tests,
pubmed-meshheading:19553435-Nuclear Proteins,
pubmed-meshheading:19553435-Occipital Lobe,
pubmed-meshheading:19553435-Parietal Lobe,
pubmed-meshheading:19553435-Period Circadian Proteins,
pubmed-meshheading:19553435-Polymorphism, Single Nucleotide,
pubmed-meshheading:19553435-Prefrontal Cortex,
pubmed-meshheading:19553435-Sleep,
pubmed-meshheading:19553435-Sleep Deprivation,
pubmed-meshheading:19553435-Tandem Repeat Sequences,
pubmed-meshheading:19553435-Temporal Lobe,
pubmed-meshheading:19553435-Time Factors,
pubmed-meshheading:19553435-Transcription Factors,
pubmed-meshheading:19553435-Wakefulness,
pubmed-meshheading:19553435-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype.
|
| pubmed:affiliation |
Cyclotron Research Centre, University of Liège, B-4000 Liège, Belgium.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|