Source:http://linkedlifedata.com/resource/pubmed/id/19553125
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2009-7-27
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| pubmed:abstractText |
Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson's disease (PD) are limited. We present a case series of 21 operated PD patients who had exhibited DDS, ICDs or punding at some stage during the disease. DDS remained unimproved or worsened post-operatively in 12/17 patients with pre-operative DDS (71%) (nine bilateral subthalamic nucleus [STN], one right-sided STN, two bilateral globus pallidus internus [GPi] DBS). DDS improved or resolved after bilateral STN DBS in 5/17 patients with pre-operative DDS. DDS apparently developed for the first time after bilateral STN DBS in two patients, although only after a latency of eight years in one case. One patient without reported pre-operative DDS or ICDs developed pathological gambling post-STN DBS. One patient had pathological gambling which resolved pre-operatively, and did not recur post-DBS. Thus, DDS, ICDs and punding may persist, worsen or develop for the first time after DBS surgery, although a minority of patients improved dramatically. Predictive factors may include physician vigilance, motor outcome and patient compliance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0967-5868
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| pubmed:author |
pubmed-author:EvansAndrew HAH,
pubmed-author:GallagherDavid ADA,
pubmed-author:KotschetKatyaK,
pubmed-author:LaceyCameronC,
pubmed-author:LawrenceAndrew DAD,
pubmed-author:LeesAndrew JAJ,
pubmed-author:LimShen-YangSY,
pubmed-author:O'SullivanDudley JDJ,
pubmed-author:O'SullivanSean SSS,
pubmed-author:PeppardRichard FRF,
pubmed-author:RodriguesJulian PJP,
pubmed-author:SchragAnetteA,
pubmed-author:SilbersteinPaulP,
pubmed-author:TischStephenS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1148-52
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| pubmed:meshHeading |
pubmed-meshheading:19553125-Adolescent,
pubmed-meshheading:19553125-Adult,
pubmed-meshheading:19553125-Deep Brain Stimulation,
pubmed-meshheading:19553125-Dopamine,
pubmed-meshheading:19553125-Female,
pubmed-meshheading:19553125-Health Care Surveys,
pubmed-meshheading:19553125-Humans,
pubmed-meshheading:19553125-Impulse Control Disorders,
pubmed-meshheading:19553125-Magnetic Resonance Imaging,
pubmed-meshheading:19553125-Male,
pubmed-meshheading:19553125-Middle Aged,
pubmed-meshheading:19553125-Movement Disorders,
pubmed-meshheading:19553125-Neurosurgical Procedures,
pubmed-meshheading:19553125-Parkinson Disease,
pubmed-meshheading:19553125-Patient Compliance,
pubmed-meshheading:19553125-Postoperative Complications,
pubmed-meshheading:19553125-Questionnaires,
pubmed-meshheading:19553125-Treatment Outcome,
pubmed-meshheading:19553125-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson's disease.
|
| pubmed:affiliation |
Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia.
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| pubmed:publicationType |
Journal Article
|