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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2009-7-14
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pubmed:abstractText |
The lead optimization process to identify new selective dopamine D(3) receptor antagonists is reported. DMPK parameters and binding data suggest that selective D(3) receptor antagonists as potential PET ligands might have been identified.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AristaLucaL,
pubmed-author:BonanomiGiorgioG,
pubmed-author:BraggioSimoneS,
pubmed-author:CardulloFrancescaF,
pubmed-author:Di FabioRomanoR,
pubmed-author:DonatiDanieleD,
pubmed-author:GentileGabriellaG,
pubmed-author:GriffanteCristianaC,
pubmed-author:HamprechtDieterD,
pubmed-author:HeidbrederChristianC,
pubmed-author:HolleyH SHS,
pubmed-author:MicheliFabrizioF,
pubmed-author:SavoiaChiaraC,
pubmed-author:TerreniSilviaS,
pubmed-author:WorbyAngelaA
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4011-3
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pubmed:meshHeading |
pubmed-meshheading:19553113-Animals,
pubmed-meshheading:19553113-Brain,
pubmed-meshheading:19553113-Chemistry, Organic,
pubmed-meshheading:19553113-Chemistry, Pharmaceutical,
pubmed-meshheading:19553113-Humans,
pubmed-meshheading:19553113-Imidazolidines,
pubmed-meshheading:19553113-Inhibitory Concentration 50,
pubmed-meshheading:19553113-Ligands,
pubmed-meshheading:19553113-Models, Chemical,
pubmed-meshheading:19553113-Positron-Emission Tomography,
pubmed-meshheading:19553113-Rats,
pubmed-meshheading:19553113-Receptors, Dopamine D2,
pubmed-meshheading:19553113-Receptors, Dopamine D3,
pubmed-meshheading:19553113-Structure-Activity Relationship,
pubmed-meshheading:19553113-Swine
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pubmed:year |
2009
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pubmed:articleTitle |
Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.
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pubmed:affiliation |
GlaxoSmithKline, Neurosciences Centre of Excellence for Drug Discovery, Medicine Research Centre, Verona, Italy. fm20244@gsk.com
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pubmed:publicationType |
Journal Article
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