rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2010-3-12
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pubmed:abstractText |
This study was prospectively conducted in 11 haematology divisions over a 2-year period to evaluate the efficacy of caspofungin in 24 neutropenic patients with haematological malignancies (HM) and candidaemia. These patients had received chemotherapy for HM and were neutropenic (PNN < 0.5 x 10(9)/L) for a median of 12 days (2-41) before candidaemia. The patients received caspofungin for a median duration of 12 days (range 6-26), obtaining a favourable overall response of 58%. At 30 days, 11 patients had died (46%); candidaemia was responsible for mortality in six patients (25%). These results suggest that treatment of candidaemia with caspofungin in neutropenic HM was efficacious, as it is in non-haematological subgroups.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1469-0691
|
pubmed:author |
pubmed-author:CairdJJ,
pubmed-author:CandoniAA,
pubmed-author:FanciRR,
pubmed-author:FarinaGG,
pubmed-author:FianchiLL,
pubmed-author:LeoneGG,
pubmed-author:MitraM EME,
pubmed-author:MorselliMM,
pubmed-author:NosariAA,
pubmed-author:OffidaniMM,
pubmed-author:PaganiFF,
pubmed-author:PosteraroBB,
pubmed-author:SanguinettiMM,
pubmed-author:TostiM EME,
pubmed-author:ValentineC CCC,
pubmed-author:VialePP
|
pubmed:issnType |
Electronic
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
298-301
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pubmed:meshHeading |
pubmed-meshheading:19549221-Adult,
pubmed-meshheading:19549221-Aged,
pubmed-meshheading:19549221-Antifungal Agents,
pubmed-meshheading:19549221-Antineoplastic Agents,
pubmed-meshheading:19549221-Candidiasis,
pubmed-meshheading:19549221-Drug Therapy,
pubmed-meshheading:19549221-Echinocandins,
pubmed-meshheading:19549221-Female,
pubmed-meshheading:19549221-Fungemia,
pubmed-meshheading:19549221-Hematologic Neoplasms,
pubmed-meshheading:19549221-Humans,
pubmed-meshheading:19549221-Male,
pubmed-meshheading:19549221-Middle Aged,
pubmed-meshheading:19549221-Neutropenia,
pubmed-meshheading:19549221-Prospective Studies,
pubmed-meshheading:19549221-Treatment Outcome,
pubmed-meshheading:19549221-Young Adult
|
pubmed:year |
2010
|
pubmed:articleTitle |
Caspofungin for the treatment of candidaemia in patients with haematological malignancies.
|
pubmed:affiliation |
Haematology and Microbiology Institutes, Catholic University, Rome, Italy. lpagano@rm.unicatt.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|