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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-6-24
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pubmed:abstractText |
Apoptosis or programmed cell death involves a number of biochemical events, including the activation of caspases, which lead to specific cell morphology changes and ultimately cell death. Traditionally, two apoptotic pathways have been described: the cell-surface death receptor-dependent extrinsic pathway and the mitochondria-dependent intrinsic pathway. Alternatively, apoptosis has been reported to be induced by endoplasmic reticulum (ER) stress, which is mainly induced by a reduction in intraluminal free Ca(2+) concentration ([Ca(2+)](ER)).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
992-9
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pubmed:meshHeading |
pubmed-meshheading:19548908-Apoptosis,
pubmed-meshheading:19548908-Blood Platelets,
pubmed-meshheading:19548908-Blotting, Western,
pubmed-meshheading:19548908-Calcium,
pubmed-meshheading:19548908-Caspase 3,
pubmed-meshheading:19548908-Caspase 8,
pubmed-meshheading:19548908-Endocytosis,
pubmed-meshheading:19548908-Endoplasmic Reticulum,
pubmed-meshheading:19548908-Enzyme Activation,
pubmed-meshheading:19548908-Ethylenediamines,
pubmed-meshheading:19548908-Humans,
pubmed-meshheading:19548908-Phosphatidylserines,
pubmed-meshheading:19548908-Phosphorylation,
pubmed-meshheading:19548908-Thrombin
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pubmed:year |
2009
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pubmed:articleTitle |
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress.
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pubmed:affiliation |
Department of Physiology, University of Extremadura, Cáceres, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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