Linked Life Data

19548341

Source:http://linkedlifedata.com/resource/pubmed/id/19548341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-6-23
pubmed:abstractText
We consider the problem of detection of modifier genes that lead to variations in a disease-related continuous variable (DRCV), such as the age of onset or a measure of disease severity, in a strategy of candidate genes. We propose a novel method, the ordered transmission disequilibrium test (OTDT), to test for a relation between the clinical heterogeneity expressed by a DRCV and marker genotypes of a candidate gene. The OTDT applies to trio families with one patients and his parents, all three genotyped at a bi-allelic marker M. The OTDT aims to find a critical value of the DRCV which separates the sample of families in two subsamples in which the transmission rates are significantly different. We investigate the power of the method by simulations under various genetic models and covariate distributions and compare it with a linear regression analysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0741-0395
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The ordered transmission disequilibrium test: detection of modifier genes.
pubmed:affiliation
INSERM U535, BP 1000, F-94817 Villejuif, France. herve.perdry@inserm.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't