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rdf:type |
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lifeskim:mentions |
umls-concept:C0015965,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205161,
umls-concept:C0205217,
umls-concept:C1414669,
umls-concept:C1449855,
umls-concept:C1522604,
umls-concept:C1527148,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-3
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pubmed:abstractText |
Previous research in fetuses with increased nuchal translucency (NT) showed abnormal lymphatic endothelial differentiation characteristics, including increased vascular endothelial growth factor (VEGF)-A expression, and aberrant smooth muscle cells (SMCs) surrounding enlarged jugular lymphatic sacs (JLS). We hypothesized that abnormal Sonic hedgehog (Shh) expression would result in altered VEGF-A signaling in the lymphatic endothelial cells of the JLS and that aberrant acquisition of SMCs could be caused by downregulation of forkhead transcription factor FOXC2 and upregulation of platelet-derived growth factor (PDGF)-B in the lymphatic endothelial cells of the JLS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-0223
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
840-6
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pubmed:meshHeading |
pubmed-meshheading:19548265-Biological Markers,
pubmed-meshheading:19548265-Blood Vessels,
pubmed-meshheading:19548265-Down Syndrome,
pubmed-meshheading:19548265-Endothelial Cells,
pubmed-meshheading:19548265-Female,
pubmed-meshheading:19548265-Fetal Development,
pubmed-meshheading:19548265-Fetal Heart,
pubmed-meshheading:19548265-Fetus,
pubmed-meshheading:19548265-Forkhead Transcription Factors,
pubmed-meshheading:19548265-Hedgehog Proteins,
pubmed-meshheading:19548265-Humans,
pubmed-meshheading:19548265-Lymphatic System,
pubmed-meshheading:19548265-Lymphatic Vessels,
pubmed-meshheading:19548265-Neck,
pubmed-meshheading:19548265-Nuchal Translucency Measurement,
pubmed-meshheading:19548265-Pregnancy,
pubmed-meshheading:19548265-Vascular Endothelial Growth Factor A
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pubmed:year |
2009
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pubmed:articleTitle |
Abnormal Shh and FOXC2 expression correlates with aberrant lymphatic development in human fetuses with increased nuchal translucency.
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pubmed:affiliation |
Department of Anatomy and Embryology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article
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