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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-8-24
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pubmed:abstractText |
Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1865-3774
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pubmed:author |
pubmed-author:AndoToshihikoT,
pubmed-author:AriyoshiKoichiK,
pubmed-author:GondoToshikazuT,
pubmed-author:KizukiNobuakiN,
pubmed-author:MitaniNoriyukiN,
pubmed-author:NakamuraYukinoriY,
pubmed-author:TagamiKozoK,
pubmed-author:TakahashiToruT,
pubmed-author:TanakaYoshinoriY,
pubmed-author:TanizawaYukioY,
pubmed-author:YujiriToshiakiT
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pubmed:issnType |
Electronic
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
248-52
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pubmed:meshHeading |
pubmed-meshheading:19548069-Acute Disease,
pubmed-meshheading:19548069-Adolescent,
pubmed-meshheading:19548069-Adult,
pubmed-meshheading:19548069-Biopsy,
pubmed-meshheading:19548069-Female,
pubmed-meshheading:19548069-Graft vs Host Disease,
pubmed-meshheading:19548069-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19548069-Humans,
pubmed-meshheading:19548069-Leukemia,
pubmed-meshheading:19548069-Male,
pubmed-meshheading:19548069-Matrix Metalloproteinase 2,
pubmed-meshheading:19548069-Matrix Metalloproteinase 9,
pubmed-meshheading:19548069-Middle Aged,
pubmed-meshheading:19548069-Skin,
pubmed-meshheading:19548069-Transplantation, Homologous,
pubmed-meshheading:19548069-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.
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pubmed:affiliation |
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
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pubmed:publicationType |
Journal Article
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