19545435

Source:http://linkedlifedata.com/resource/pubmed/id/19545435

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003009, umls-concept:C0003483, umls-concept:C0034693, umls-concept:C0126174, umls-concept:C0205409, umls-concept:C1335631
pubmed:dateCreated	2009-7-17
pubmed:abstractText	In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an AT-II receptor antagonist.We now aimed to investigate the effect of treating diabetic STZ-rats with losartan on diabetes vascular response to vasoconstrictors.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101147637
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp..., http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II, http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Losartan, http://linkedlifedata.com/resource/pubmed/chemical/ROCK1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles, http://linkedlifedata.com/resource/pubmed/chemical/fasudil, http://linkedlifedata.com/resource/pubmed/chemical/irbesartan, http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
pubmed:status	MEDLINE
pubmed:issn	1475-2840
pubmed:author	pubmed-author:AlfaranoChiaraC, pubmed-author:CerbaiElisabettaE, pubmed-author:FailliPaolaP, pubmed-author:Franchi-MicheliSergioS, pubmed-author:MannucciEdoardoE, pubmed-author:MugelliAlessandroA, pubmed-author:RaimondiLauraL
pubmed:issnType	Electronic
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	32
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:19545435-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, pubmed-meshheading:19545435-Angiotensin II, pubmed-meshheading:19545435-Animals, pubmed-meshheading:19545435-Aorta, Thoracic, pubmed-meshheading:19545435-Biphenyl Compounds, pubmed-meshheading:19545435-Diabetes Mellitus, Experimental, pubmed-meshheading:19545435-Losartan, pubmed-meshheading:19545435-Male, pubmed-meshheading:19545435-Rats, pubmed-meshheading:19545435-Rats, Wistar, pubmed-meshheading:19545435-Tetrazoles, pubmed-meshheading:19545435-Up-Regulation, pubmed-meshheading:19545435-Vasoconstriction, pubmed-meshheading:19545435-rho-Associated Kinases
pubmed:year	2009
pubmed:articleTitle	Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.
pubmed:affiliation	Dept. of Pharmacology, University of Florence, Viale G, Pieraccini 6, Florence, Italy. paola.failli@unifi.it
pubmed:publicationType	Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't