Source:http://linkedlifedata.com/resource/pubmed/id/19542882
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2009-8-13
|
| pubmed:abstractText |
In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction. Ninety-seven patients who were under aspirin therapy and hospitalized with unstable angina/non-ST elevation myocardial infarction were included in the study. Laboratory-defined aspirin sensitive and resistant groups were determined by platelet function analyzer; aspirin resistance was defined as collagen/epinephrine closure time less than 165 s. Laboratory-defined aspirin resistance was noted in 29 patients (29.9%), and non-ST elevation myocardial infarction was observed in 46 patients (47.4%). Patients in the group with laboratory-defined aspirin resistance had significantly higher thrombolysis in myocardial infarction risk scores (P < 0.001). When the details of cardiac myonecrosis markers were compared, baseline and follow-up creatine kinase-myocardial band and troponin I values were higher in laboratory-defined aspirin-resistant group. Multivariate analyses revealed that laboratory-defined aspirin resistance was an independent predictor of non-ST elevation myocardial infarction (P = 0.022). Laboratory-defined aspirin resistance is associated with non-ST elevation myocardial infarction, higher markers of cardiac necrosis and thrombolysis in myocardial infarction risk score in patients hospitalized with unstable angina/non-ST elevation myocardial infarction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
1473-5733
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
427-32
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| pubmed:meshHeading |
pubmed-meshheading:19542882-Acute Coronary Syndrome,
pubmed-meshheading:19542882-Aged,
pubmed-meshheading:19542882-Angina, Unstable,
pubmed-meshheading:19542882-Aspirin,
pubmed-meshheading:19542882-Comorbidity,
pubmed-meshheading:19542882-Drug Resistance,
pubmed-meshheading:19542882-Electrocardiography,
pubmed-meshheading:19542882-Female,
pubmed-meshheading:19542882-Humans,
pubmed-meshheading:19542882-Inflammation,
pubmed-meshheading:19542882-Male,
pubmed-meshheading:19542882-Middle Aged,
pubmed-meshheading:19542882-Myocardial Infarction,
pubmed-meshheading:19542882-Myocardium,
pubmed-meshheading:19542882-Necrosis,
pubmed-meshheading:19542882-Platelet Activation,
pubmed-meshheading:19542882-Platelet Aggregation Inhibitors,
pubmed-meshheading:19542882-Platelet Function Tests,
pubmed-meshheading:19542882-Risk Factors,
pubmed-meshheading:19542882-Severity of Illness Index,
pubmed-meshheading:19542882-Thrombophilia
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes.
|
| pubmed:affiliation |
Faculty of Medicine, Department of Cardiology, Ministry of Health Di?kapi Yildirim Beyazit Research and Educational Hospital, Baskent University, Ankara, Turkey. sadik.acikel@tkd.org.tr
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| pubmed:publicationType |
Journal Article,
Comparative Study
|