Source:http://linkedlifedata.com/resource/pubmed/id/19542441
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-6-22
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| pubmed:abstractText |
The rising incidence of autoimmune diseases such as multiple sclerosis (MS) in developed countries might be due to a more hygienic environment, particularly during early life. To investigate this concept, we developed a model of neonatal exposure to a common pathogen-associated molecular pattern, LPS, and determined its impact on experimental autoimmune encephalomyelitis (EAE). Mice exposed to LPS at 2 wk of age showed a delayed onset and diminished severity of myelin oligodendrocyte glycoprotein (MOG)-induced EAE, induced at 12 wk, compared with vehicle-exposed animals. Spinal cord transcript levels of CD3epsilon and F4/80 were lower in LPS- compared with PBS-exposed EAE animals with increased IL-10 levels in the LPS-exposed group. Splenic CD11c(+) cells from LPS-exposed animals exhibited reduced MHC class II and CD83 expression but increased levels of CD80 and CD86 both before and during EAE. MOG-treated APC from LPS-exposed animals stimulated less T lymphocyte proliferation but increased expansion of CD4(+)FoxP3(+) T cells compared with APC from PBS-exposed animals. Neuropathological studies disclosed reduced myelin and axonal loss in spinal cords from LPS-exposed compared with PBS-exposed animals with EAE, and this neuroprotective effect was associated with an increased number of CD3(+)FoxP3(+) immunoreactive cells. Analyses of human brain tissue revealed that FoxP3 expression was detected in lymphocytes, albeit reduced in MS compared with non-MS patients' brains. These findings support the concept of early-life microbial exposure influencing the generation of neuroprotective regulatory T cells and may provide insights into new immunotherapeutic strategies for MS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
183
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
298-309
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| pubmed:meshHeading |
pubmed-meshheading:19542441-Animals,
pubmed-meshheading:19542441-Animals, Newborn,
pubmed-meshheading:19542441-Brain,
pubmed-meshheading:19542441-Cell Differentiation,
pubmed-meshheading:19542441-Cell Movement,
pubmed-meshheading:19542441-Cells, Cultured,
pubmed-meshheading:19542441-Coculture Techniques,
pubmed-meshheading:19542441-Dendritic Cells,
pubmed-meshheading:19542441-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:19542441-Female,
pubmed-meshheading:19542441-Forkhead Transcription Factors,
pubmed-meshheading:19542441-Immune Tolerance,
pubmed-meshheading:19542441-Interleukin-10,
pubmed-meshheading:19542441-Lipopolysaccharides,
pubmed-meshheading:19542441-Mice,
pubmed-meshheading:19542441-Mice, Inbred C57BL,
pubmed-meshheading:19542441-Multiple Sclerosis,
pubmed-meshheading:19542441-Neuroprotective Agents,
pubmed-meshheading:19542441-Severity of Illness Index,
pubmed-meshheading:19542441-T-Lymphocytes, Regulatory
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| pubmed:year |
2009
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| pubmed:articleTitle |
Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.
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| pubmed:affiliation |
Department of Medicine, University of Alberta, Edmonton, Canada.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|