Linked Life Data

19540811

Source:http://linkedlifedata.com/resource/pubmed/id/19540811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-7-6
pubmed:abstractText
Infection of the aero-digestive tract represents a major disease burden of the elderly, and despite recent advances in our understanding of the mucosal immune system, its immunosenescence remains poorly defined. Age-associated alterations of the intestinal and respiratory immune systems occur at distinct times and in a distinct manner. A reduction in gut-associated lymphoreticular tissues, intestinal antigen-specific IgA antibody responses and lack of oral tolerance induction are all associated with aging. By contrast, nasopharyngeal-associated lymphoreticular tissue function remains intact during aging with notable signs of immunosenescence seen only in the elderly. The distinct timing of mucosal immunosenescence seen between the gut and respiratory system suggests the nasal route of vaccination might be preferable for effective mucosal vaccines in the elderly.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1471-4981
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
334-43
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Mucosal immunosenescence: new developments and vaccines to control infectious diseases.
pubmed:affiliation
Departments of Pediatric Dentistry and Microbiology, The Immunobiology Vaccine Center, The Institute of Oral Health Research, The University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA. kohtarof@uab.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural