| pubmed-article:1954076 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1954076 | lifeskim:mentions | umls-concept:C0034417 | lld:lifeskim |
| pubmed-article:1954076 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:1954076 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:1954076 | lifeskim:mentions | umls-concept:C0011082 | lld:lifeskim |
| pubmed-article:1954076 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:1954076 | lifeskim:mentions | umls-concept:C0030011 | lld:lifeskim |
| pubmed-article:1954076 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1954076 | pubmed:dateCreated | 1991-12-30 | lld:pubmed |
| pubmed-article:1954076 | pubmed:abstractText | The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of quinine after a single dose (600 mg) of quinine sulphate was studied in eight extensive metabolizers (EM) and five poor metabolizers (PM). The mean elimination half-life of quinine in the PMs (10.2 +/- 1.6 (s.d.)h) was similar to that in the EMs (10.9 +/- 1.7 h). The oral clearance of quinine in the PM subjects was 0.092 +/- 0.021 l h-1 kg-1 and was not significantly different (P greater than 0.05) from that observed in the EM subjects (0.073 +/- 0.019 l h-1 kg-1). This suggests that even though quinine is extensively metabolized by oxidative biotransformation, this is carried out largely by P450 isoenzymes different from P450IID6 which oxidizes debrisoquine. | lld:pubmed |
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| pubmed-article:1954076 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1954076 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1954076 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1954076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1954076 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1954076 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1954076 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:1954076 | pubmed:author | pubmed-author:WanwimolrukSS | lld:pubmed |
| pubmed-article:1954076 | pubmed:author | pubmed-author:ChalcroftSS | lld:pubmed |
| pubmed-article:1954076 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1954076 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:1954076 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1954076 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1954076 | pubmed:pagination | 617-20 | lld:pubmed |
| pubmed-article:1954076 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
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| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:meshHeading | pubmed-meshheading:1954076-... | lld:pubmed |
| pubmed-article:1954076 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1954076 | pubmed:articleTitle | Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics of quinine. | lld:pubmed |
| pubmed-article:1954076 | pubmed:affiliation | School of Pharmacy, University of Otago, Dunedin, New Zealand. | lld:pubmed |
| pubmed-article:1954076 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1954076 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1954076 | lld:pubmed |
