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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1991-12-30
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pubmed:abstractText |
The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of quinine after a single dose (600 mg) of quinine sulphate was studied in eight extensive metabolizers (EM) and five poor metabolizers (PM). The mean elimination half-life of quinine in the PMs (10.2 +/- 1.6 (s.d.)h) was similar to that in the EMs (10.9 +/- 1.7 h). The oral clearance of quinine in the PM subjects was 0.092 +/- 0.021 l h-1 kg-1 and was not significantly different (P greater than 0.05) from that observed in the EM subjects (0.073 +/- 0.019 l h-1 kg-1). This suggests that even though quinine is extensively metabolized by oxidative biotransformation, this is carried out largely by P450 isoenzymes different from P450IID6 which oxidizes debrisoquine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-2049234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-2306418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-2570698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-3123997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-3514607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-3567021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-3748010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-3780830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-3893840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-6498616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-6626434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1954076-7075085
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
617-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1991
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pubmed:articleTitle |
Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics of quinine.
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pubmed:affiliation |
School of Pharmacy, University of Otago, Dunedin, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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