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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-11-2
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|
pubmed:abstractText |
Immunohistochemical staining using human normal ovaries showed that bone morphogenetic protein-6 (BMP-6) was abundantly present in the granulosa cells (GC) of healthy tertiary follicles but not in atretic follicles. An in vitro study showed that BMP-6 induced gene expression of FSH receptor, inhibin/activin beta subunits, and anti-Müllerian hormone (AMH) in human GCs, suggesting that BMP-6 is an important mediator to support healthy follicle growth in the human ovary.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1556-5653
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1794-8
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pubmed:meshHeading |
pubmed-meshheading:19539911-Adult,
pubmed-meshheading:19539911-Anti-Mullerian Hormone,
pubmed-meshheading:19539911-Bone Morphogenetic Protein 6,
pubmed-meshheading:19539911-Cells, Cultured,
pubmed-meshheading:19539911-Female,
pubmed-meshheading:19539911-Gene Expression Regulation,
pubmed-meshheading:19539911-Granulosa Cells,
pubmed-meshheading:19539911-Humans,
pubmed-meshheading:19539911-Inhibin-beta Subunits,
pubmed-meshheading:19539911-Ovarian Follicle,
pubmed-meshheading:19539911-Ovary,
pubmed-meshheading:19539911-Receptors, FSH
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pubmed:year |
2009
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pubmed:articleTitle |
Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Müllerian hormone in human granulosa cells.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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