Source:http://linkedlifedata.com/resource/pubmed/id/19539693
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2009-8-14
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pubmed:abstractText |
Cloned placenta immunoregulatory ferritin (PLIF) contains a novel, nonferritin bioactive domain (C-48) with immunodulatory activity. We documented that treatment of whole human bone marrow cells with PLIF and its subcloned C48 proteins resulted in myeloid progenitor cell growth and differentiation and T-cell suppression via an effect on the cytokine network. We tested whether this differential effect supports allogeneic bone marrow transplantation with long-lasting tolerance without any further treatments.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1873-2399
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1121-30
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pubmed:meshHeading |
pubmed-meshheading:19539693-Animals,
pubmed-meshheading:19539693-Bone Marrow Transplantation,
pubmed-meshheading:19539693-Female,
pubmed-meshheading:19539693-Ferritins,
pubmed-meshheading:19539693-Graft vs Host Disease,
pubmed-meshheading:19539693-Humans,
pubmed-meshheading:19539693-Immunologic Factors,
pubmed-meshheading:19539693-Male,
pubmed-meshheading:19539693-Mice,
pubmed-meshheading:19539693-Mice, Inbred C3H,
pubmed-meshheading:19539693-Mice, Inbred DBA,
pubmed-meshheading:19539693-Myeloid Progenitor Cells,
pubmed-meshheading:19539693-Protein Structure, Tertiary,
pubmed-meshheading:19539693-Recombinant Proteins,
pubmed-meshheading:19539693-Transplantation, Homologous,
pubmed-meshheading:19539693-Transplantation Chimera
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pubmed:year |
2009
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pubmed:articleTitle |
A proof of concept study: human C48-placenta immunoregulatory factor is an effective, single therapeutic agent enabling allogeneic, nonmanipulated murine bone marrow transplantation.
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pubmed:affiliation |
Laboratory of Molecular Immunology, Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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