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rdf:type |
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lifeskim:mentions |
umls-concept:C0028953,
umls-concept:C0030956,
umls-concept:C0056912,
umls-concept:C0205314,
umls-concept:C0208973,
umls-concept:C0678209,
umls-concept:C0679622,
umls-concept:C1517892,
umls-concept:C1519886,
umls-concept:C1704666,
umls-concept:C1704735,
umls-concept:C1883254
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pubmed:issue |
34
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pubmed:dateCreated |
2009-7-8
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pubmed:abstractText |
There has been an increased demand for the development of novel vaccine adjuvants that lead to enhanced induction of protection from infectious challenges and development of immunological memory. A novel vaccine adjuvant was developed comprising a complex containing CpG oligonucleotide and the synthetic cationic innate defence regulator peptide HH2 that has enhanced immune modulating activities. The complex of HH2 and the CpG oligonucleotide 10101 was a potent inducer of cytokine/chemokine expression ex vivo, retained activity following extended storage, had low associated cytotoxicity, and upregulated surface marker expression in dendritic cells, a critical activity for a vaccine adjuvant. Immunization of mice with a coformulation of the HH2-CpG complex and pertussis toxoid significantly enhanced the induction of toxoid-specific antibody titres when compared to toxoid alone, inducing high titres of IgG1 and IgG2a, typical of a balanced Th1/Th2 response, and also led to high IgA titres. This study demonstrates the potential application of the HH2-CpG complex as a vaccine adjuvant.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antitoxins,
http://linkedlifedata.com/resource/pubmed/chemical/CPG 10101,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Toxoids,
http://linkedlifedata.com/resource/pubmed/chemical/pertussis toxoid
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-2518
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4662-71
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pubmed:meshHeading |
pubmed-meshheading:19539585-Adjuvants, Immunologic,
pubmed-meshheading:19539585-Animals,
pubmed-meshheading:19539585-Antibodies, Bacterial,
pubmed-meshheading:19539585-Antitoxins,
pubmed-meshheading:19539585-Cytokines,
pubmed-meshheading:19539585-Dendritic Cells,
pubmed-meshheading:19539585-Drug Stability,
pubmed-meshheading:19539585-Female,
pubmed-meshheading:19539585-Immunity,
pubmed-meshheading:19539585-Immunity, Innate,
pubmed-meshheading:19539585-Immunoglobulin A,
pubmed-meshheading:19539585-Immunoglobulin G,
pubmed-meshheading:19539585-Mice,
pubmed-meshheading:19539585-Mice, Inbred BALB C,
pubmed-meshheading:19539585-Oligodeoxyribonucleotides,
pubmed-meshheading:19539585-Peptides,
pubmed-meshheading:19539585-Pertussis Vaccine,
pubmed-meshheading:19539585-Toxoids
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pubmed:year |
2009
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pubmed:articleTitle |
A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity.
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pubmed:affiliation |
Centre for Microbial Diseases and Immunity Research, University of British Columbia, BC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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