Linked Life Data

19537096

Source:http://linkedlifedata.com/resource/pubmed/id/19537096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-6-19
pubmed:abstractText
Twenty-four hours after intramuscular injection of Stimforte in a dose of 25 microg in mice weighing 18-20 g, chronically infected with hepatitis C virus (HCV), viral infection was shown to be at the most suppressed viral replication, as suggested by the data of the infectious and antigenic activities of HCV. Following 72 hours of its administration, the quantity of viral antigen and the infectious activity restored. Readministration of the agent considerably suppressed HCV replication. When given in a dose of 12.5 microg/kg, the agent reduced HCV titers by 2.0-2.5 log10 TCID50; when used in a dose of 25 microg/kg, it diminished the infectious activity of HCV by 3.2 log. The similar data were obtained in the study of the antigenic activity of HCV in infected animals. The effect of Virazole in combination with Stimforte in reducing the replication of infectious HCV and the accumulation of antigens in HCV-infected mice was additive or synergic, suggesting that it is expedient to use them concurrently.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-4088
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-5
pubmed:meshHeading
pubmed:articleTitle
[Effect of Stimforte in combination with Virazole on infection induced by hepatitis C virus in mice].
pubmed:publicationType
Journal Article, English Abstract