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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1991-12-16
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pubmed:abstractText |
A new G-protein was detected in human platelets which was ADP-ribosylated in a pertussis-toxin-dependent manner, was located in the supernatant of saponized platelets and was of a slightly lower molecular mass (40 kDa) than platelet membrane Gi alpha. This soluble ADP-ribosylated protein was immunoprecipitated by an antiserum to Gi alpha, but not by one to Go alpha. Prior thrombin stimulation of platelets led to an inhibition of the ADP-ribosylation of this protein. This inhibition was evident even under conditions which abolished the thrombin-stimulated inhibition of membrane Gi alpha ADP-ribosylation. These results indicate that the platelet thrombin receptor is coupled to two structurally and functionally distinct Gi alpha proteins: a major Gi alpha protein present in platelet membranes, and a minor Gi alpha protein detectable in the platelet soluble fraction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-1693774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2105488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2115889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2116927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2153964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2169434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2333284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2446610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2510151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2536184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2538814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2574568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2820999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2830284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2834384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-2848502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3001080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3023354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3023367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3080417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3083418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3087970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3106040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3109953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3110783,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-3461464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-4052085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-409714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-6411729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-6437813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-656619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953657-7391039
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
279 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1953657-Adenosine Diphosphate Ribose,
pubmed-meshheading:1953657-Animals,
pubmed-meshheading:1953657-Blotting, Western,
pubmed-meshheading:1953657-Cattle,
pubmed-meshheading:1953657-GTP-Binding Proteins,
pubmed-meshheading:1953657-Humans,
pubmed-meshheading:1953657-Pertussis Toxin,
pubmed-meshheading:1953657-Platelet Aggregation,
pubmed-meshheading:1953657-Platelet Aggregation Inhibitors,
pubmed-meshheading:1953657-Solubility,
pubmed-meshheading:1953657-Thrombin,
pubmed-meshheading:1953657-Virulence Factors, Bordetella
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pubmed:year |
1991
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pubmed:articleTitle |
Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.
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pubmed:affiliation |
Institut für Prophylaxe und Epidemiologie, Universität München, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article
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