Linked Life Data

19536484

Source:http://linkedlifedata.com/resource/pubmed/id/19536484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-6-18
pubmed:abstractText
Chelation of iron in in vitro carotid body emulates the effects of hypoxia. The role iron plays in in vivo ventilatory responses is unclear. In the current study we addressed this issue by examining the effects of chronic iron chelation on the hypoxic ventilatory response in 9 conscious Wistar rats. Acute responses to 14 and 9% O(2)in N(2) were recorded in the same rat before and then after 7 and 14 days of continuous iron chelation. Iron chelation was carried out with ciclopirox olamine (CPX) in a dose of 20 mg/kg daily, i.p. Ventilation was recorded with whole body plethysmography. We found that the peak hypoxic ventilation (V(E) achieved during 14 and 9% hypoxia was lower by 239.6+/-55.4(SE) and 269.6.2+/-69.2 ml min(-1)kg(-1), respectively, in the rats treated with CPX for 7 days. The decreases were not intensified by a longer duration of iron chelation. CPX failed to alter hypoxic sensitivity, assessed from the gain of peak V(E) with increasing strength of the hypoxic stimulus. In conclusion, we believe we have shown that iron is operational in shaping the hypoxic ventilatory response, but is not liable to be the underlying determinant of the hypoxic chemoreflex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
648
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-21
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Iron chelation and the ventilatory response to hypoxia.
pubmed:affiliation
Department of Respiratory Research, Medical Research Center, Polish Academy of Science, Warsaw, Poland. m_pokorski@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't