19536088

Source:http://linkedlifedata.com/resource/pubmed/id/19536088

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006142, umls-concept:C0017262, umls-concept:C0018270, umls-concept:C0026336, umls-concept:C0027651, umls-concept:C0185117, umls-concept:C0591833, umls-concept:C2911684
pubmed:issue	2
pubmed:dateCreated	2009-7-15
pubmed:abstractText	Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but cleavage by pregnancy-associated plasma protein-A (PAPP-A) protease releases active IGF1.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370635
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding..., http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I, http://linkedlifedata.com/resource/pubmed/chemical/Pregnancy-Associated Plasma..., http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1532-1827
pubmed:author	pubmed-author:CurridC ACA, pubmed-author:FitzpatrickP APA, pubmed-author:HarmeyJ HJH, pubmed-author:NapoletanoSS, pubmed-author:O'SullivanN CNC, pubmed-author:RyanA JAJ
pubmed:issnType	Electronic
pubmed:day	21
pubmed:volume	101
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	278-86
pubmed:dateRevised	2010-9-27
pubmed:meshHeading	pubmed-meshheading:19536088-Adenocarcinoma, pubmed-meshheading:19536088-Animals, pubmed-meshheading:19536088-Apoptosis, pubmed-meshheading:19536088-Cell Growth Processes, pubmed-meshheading:19536088-Disease Models, Animal, pubmed-meshheading:19536088-Humans, pubmed-meshheading:19536088-Insulin-Like Growth Factor Binding Protein 4, pubmed-meshheading:19536088-Insulin-Like Growth Factor I, pubmed-meshheading:19536088-Mammary Neoplasms, Experimental, pubmed-meshheading:19536088-Mice, pubmed-meshheading:19536088-Mice, Inbred BALB C, pubmed-meshheading:19536088-Mutation, pubmed-meshheading:19536088-Neovascularization, Pathologic, pubmed-meshheading:19536088-Pregnancy-Associated Plasma Protein-A, pubmed-meshheading:19536088-Receptor, IGF Type 1, pubmed-meshheading:19536088-Recombinant Proteins, pubmed-meshheading:19536088-Vascular Endothelial Growth Factor A
pubmed:year	2009
pubmed:articleTitle	Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer.
pubmed:affiliation	Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't