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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
14
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pubmed:dateCreated |
2009-7-15
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pubmed:abstractText |
The azo coupling of the antibiotic olivomycin I (1) with aryl diazonium tetrafluoroborates produced 5-aryldiazenyl-6-O-deglycosyl derivatives of 1. The structures of new compounds were confirmed by (1)H NMR and mass spectrometry analysis. A quantum-chemical study was performed to analyze the possible directions of electrophilic substitution of 1 and the easiness of 6-O-disaccharide hydrolysis in the course of azo coupling. The antiproliferative and anti-retroviral activities of novel derivatives were studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4961-7
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pubmed:meshHeading |
pubmed-meshheading:19535252-Animals,
pubmed-meshheading:19535252-Antibiotics, Antineoplastic,
pubmed-meshheading:19535252-Boric Acids,
pubmed-meshheading:19535252-Cell Line, Tumor,
pubmed-meshheading:19535252-Cell Proliferation,
pubmed-meshheading:19535252-Diazonium Compounds,
pubmed-meshheading:19535252-Humans,
pubmed-meshheading:19535252-Microbial Sensitivity Tests,
pubmed-meshheading:19535252-Molecular Structure,
pubmed-meshheading:19535252-Olivomycins,
pubmed-meshheading:19535252-Viruses
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pubmed:year |
2009
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pubmed:articleTitle |
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
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pubmed:affiliation |
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 B. Pirogovskaya, Moscow 119021, Russian Federation.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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