Linked Life Data

19535210

Source:http://linkedlifedata.com/resource/pubmed/id/19535210

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-7-20
pubmed:abstractText
The permeation of essential oils through SkinEthic reconstructed human epidermis, (RHE), was studied in vitro to establish a convenient tool to monitor the kinetics of release of active principles from cosmetic formulations. Twelve days old human epidermis held on polycarbonate disks was revitalized by addition of growth medium and incubated at 37 degrees C in 5% CO(2) atmosphere for five days prior to investigation. A system of six custom designed glass Franz-type diffusion cells were used for the permeation studies at 34 degrees C. The diffusion kinetic for 8 selected terpenes (camphor, carvone, 1,8-cineole, linalool, menthol, alpha-thujone, menthone, t-anethole), chosen as analytical markers of a mixture of plant essential oils contained in a cosmetic formulation, was probed by HS/SPME-GC-MS analysis and elaborated according to Fick's first law to obtain skin permeability coefficients (P(S) = 1.51, 1.47, 1.36, 0.80, 0.62, 0.40 and 0.14x10(-3) cm/h, respectively). The method proved to be sensitive, simple and reproducible, and RHE represents a convenient model for safety/quality assessment of cosmetic formulations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-264X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
370-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
In vitro evaluation of the permeation through reconstructed human epidermis of essentials oils from cosmetic formulations.
pubmed:affiliation
BeC S.r.l., R&D Division, Via C. Monteverdi 49, 47100 Forlì, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't