Twist is a transcription factor that plays an important role in proliferation and tumorigenesis. Twist is a nuclear protein that regulates a variety of cellular functions controlled by protein-protein interactions and gene transcription events. The focus of this study was to characterize putative nuclear localization signals (NLSs) 37RKRR40 and 73KRGKK77 in the human TWIST (H-TWIST) protein.
Department of Physiology, Charles H, Best Institute, University of Toronto, 112 College Street, Toronto, Ontario, M5G 1L6, Canada. shalini.singh@utoronto.ca
