Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2009-7-14
pubmed:abstractText
Charged, surface-active serum proteins can severely reduce or eliminate the adsorption of lung surfactant from the subphase to the alveolar air-liquid interface via a kinetically controlled competitive adsorption process. The decreased surfactant concentration at the interface leads to higher surface tensions during the compression of the interface during breathing. The correspondence between the factors governing colloid stability and competitive adsorption is validated via a new method of measuring surfactant and serum protein adsorption rates to the air-water interface, using quantitative Brewster angle microscopy (BAM). Competitive adsorption from a 10 mg/mL albumin subphase prevents the adsorption of lung surfactant from even high subphase concentrations due to the fast diffusion of the water-soluble proteins to the interface. The formation of an albumin film causes an electrostatic and steric barrier to subsequent surfactant adsorption, which can destroy the necessary properties of functional lung surfactant: low surface tension during compression and rapid respreading after film collapse. Surfactant inactivation is at least partially due to decreased surfactant adsorption; such decreased adsorption due to the presence of serum proteins may play a role in the development and severity of acute respiratory distress syndrome.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-10512825, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-10624757, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-10828579, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-10866963, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-10920022, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-11008997, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-11029372, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-11423439, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-11737935, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-11806925, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-12006806, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-12366061, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-12679861, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-12959931, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-14672849, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-14747325, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-15329426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-15454404, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-15501950, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-15671432, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-15923228, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-15951375, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16006630, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16043109, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16236739, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16394785, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16405864, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16853569, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-16864690, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-17040987, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-17156743, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-17287298, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-17416614, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-1752956, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-17662121, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-17897082, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-18005903, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-18036553, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-18433716, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-18501754, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-18515069, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-18691048, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-3233711, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-3841303, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-7647159, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-8913596, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-8982283, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-8994633, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-9105072, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-9609406, http://linkedlifedata.com/resource/pubmed/commentcorrection/19534502-9635752
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0743-7463
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8131-43
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Competitive adsorption: a physical model for lung surfactant inactivation.
pubmed:affiliation
Department of Physics, California Polytechnic University, San Luis Obispo, CA 93407, USA. jfernsle@calpoly.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural