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pubmed-article:19533849pubmed:abstractTextExamination of the genetic structure of complex diseases by a "genomic pathway approach"--which applies stepwise model selection to sets of more than 1000 polymorphisms in studies of several hundred subjects--has recently been proposed. Models constructed through extensive selection procedures may yield misleading test statistics and measures of predictive performance; we aimed to quantify the extent of such problems inherent to stepwise regression on the genomic pathway scale.lld:pubmed
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pubmed-article:19533849pubmed:articleTitleThe novel "genomic pathway approach" to complex diseases: a reason for (over-)optimism?lld:pubmed
pubmed-article:19533849pubmed:affiliationDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer St. 20, D-69115 Heidelberg, Germany. L.Breitling@dkfz.delld:pubmed
pubmed-article:19533849pubmed:publicationTypeJournal Articlelld:pubmed
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