Linked Life Data

19533849

Source:http://linkedlifedata.com/resource/pubmed/id/19533849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-6-16
pubmed:abstractText
Examination of the genetic structure of complex diseases by a "genomic pathway approach"--which applies stepwise model selection to sets of more than 1000 polymorphisms in studies of several hundred subjects--has recently been proposed. Models constructed through extensive selection procedures may yield misleading test statistics and measures of predictive performance; we aimed to quantify the extent of such problems inherent to stepwise regression on the genomic pathway scale.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1531-5487
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
500-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The novel "genomic pathway approach" to complex diseases: a reason for (over-)optimism?
pubmed:affiliation
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer St. 20, D-69115 Heidelberg, Germany. L.Breitling@dkfz.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't