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pubmed-article:19533660pubmed:abstractTextDespite advances in therapy, outcome in many high-grade pediatric central nervous system (CNS) tumors remains poor. The focus of neuro-oncology research has thus turned towards identifying novel therapeutic targets. Poly(ADP-ribose) polymerase-1 (PARP1) is a DNA repair protein that has been studied in a variety of malignancies and may interfere with therapy-induced DNA damage, however expression in pediatric CNS tumors is unknown.lld:pubmed
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pubmed-article:19533660pubmed:articleTitlePARP1 expression in pediatric central nervous system tumors.lld:pubmed
pubmed-article:19533660pubmed:affiliationDepartment of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA. valerie.barton@ucdenver.edulld:pubmed
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