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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-10-19
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pubmed:abstractText |
Despite advances in therapy, outcome in many high-grade pediatric central nervous system (CNS) tumors remains poor. The focus of neuro-oncology research has thus turned towards identifying novel therapeutic targets. Poly(ADP-ribose) polymerase-1 (PARP1) is a DNA repair protein that has been studied in a variety of malignancies and may interfere with therapy-induced DNA damage, however expression in pediatric CNS tumors is unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1545-5017
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1227-30
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pubmed:meshHeading |
pubmed-meshheading:19533660-Central Nervous System Neoplasms,
pubmed-meshheading:19533660-Child,
pubmed-meshheading:19533660-Choroid Plexus Neoplasms,
pubmed-meshheading:19533660-DNA Damage,
pubmed-meshheading:19533660-DNA Repair,
pubmed-meshheading:19533660-Drug Delivery Systems,
pubmed-meshheading:19533660-Gene Expression Profiling,
pubmed-meshheading:19533660-Glioma,
pubmed-meshheading:19533660-Humans,
pubmed-meshheading:19533660-Neoplasm Proteins,
pubmed-meshheading:19533660-Neuroectodermal Tumors, Primitive,
pubmed-meshheading:19533660-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19533660-Papilloma,
pubmed-meshheading:19533660-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:19533660-RNA, Messenger,
pubmed-meshheading:19533660-RNA, Neoplasm,
pubmed-meshheading:19533660-Single-Blind Method
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pubmed:year |
2009
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pubmed:articleTitle |
PARP1 expression in pediatric central nervous system tumors.
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pubmed:affiliation |
Department of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA. valerie.barton@ucdenver.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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