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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-6-24
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pubmed:abstractText |
We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1435-1463
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
821-30
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pubmed:meshHeading |
pubmed-meshheading:19533293-Adult,
pubmed-meshheading:19533293-Binding, Competitive,
pubmed-meshheading:19533293-Brain,
pubmed-meshheading:19533293-Brain Mapping,
pubmed-meshheading:19533293-Cerebral Cortex,
pubmed-meshheading:19533293-Female,
pubmed-meshheading:19533293-Humans,
pubmed-meshheading:19533293-Male,
pubmed-meshheading:19533293-Memory, Short-Term,
pubmed-meshheading:19533293-Pain,
pubmed-meshheading:19533293-Pain Threshold,
pubmed-meshheading:19533293-Physical Stimulation,
pubmed-meshheading:19533293-Piperazines,
pubmed-meshheading:19533293-Positron-Emission Tomography,
pubmed-meshheading:19533293-Psychophysics,
pubmed-meshheading:19533293-Pyridines,
pubmed-meshheading:19533293-Radioligand Assay,
pubmed-meshheading:19533293-Raphe Nuclei,
pubmed-meshheading:19533293-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:19533293-Serotonin,
pubmed-meshheading:19533293-Serotonin Antagonists,
pubmed-meshheading:19533293-Signal Detection, Psychological,
pubmed-meshheading:19533293-Touch
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pubmed:year |
2009
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pubmed:articleTitle |
Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch.
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pubmed:affiliation |
Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland Ilkka.Martikainen@utu.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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