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rdf:type |
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lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0015663,
umls-concept:C0202042,
umls-concept:C0205195,
umls-concept:C1171304,
umls-concept:C1280500,
umls-concept:C1415014,
umls-concept:C1415015,
umls-concept:C1417019,
umls-concept:C1428751,
umls-concept:C1442506,
umls-concept:C1882417
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-11
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pubmed:abstractText |
Variation in fasting plasma glucose (FPG) within the normal range is a known risk factor for the development of type 2 diabetes. Several reports have shown that genetic variation in the genes for glucokinase (GCK), glucokinase regulatory protein (GCKR), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2) and melatonin receptor type 1B (MTNR1B) is associated with FPG. In this study we examined whether these loci also contribute to type 2 diabetes susceptibility.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-10207722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-10491751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-10828991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-11311100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-11723071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-11867360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-15677518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-17020404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-17463246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-18008060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-18451265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-18521185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-18556336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-18678614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19008988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19016616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19060907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19060908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19060909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19096518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19533084-19209188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/G6PC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GCKR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glucokinase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose-6-Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melatonin, MT2
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1432-0428
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1866-70
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pubmed:meshHeading |
pubmed-meshheading:19533084-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19533084-Blood Glucose,
pubmed-meshheading:19533084-Cohort Studies,
pubmed-meshheading:19533084-Diabetes Mellitus, Type 2,
pubmed-meshheading:19533084-Fasting,
pubmed-meshheading:19533084-Female,
pubmed-meshheading:19533084-Genetic Predisposition to Disease,
pubmed-meshheading:19533084-Glucokinase,
pubmed-meshheading:19533084-Glucose Intolerance,
pubmed-meshheading:19533084-Glucose-6-Phosphatase,
pubmed-meshheading:19533084-Humans,
pubmed-meshheading:19533084-Male,
pubmed-meshheading:19533084-Middle Aged,
pubmed-meshheading:19533084-Polymorphism, Single Nucleotide,
pubmed-meshheading:19533084-Receptor, Melatonin, MT2,
pubmed-meshheading:19533084-Reference Values,
pubmed-meshheading:19533084-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
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pubmed:affiliation |
Department of Molecular Cell Biology, Leiden University Medical Centre, PO Box 9600, 2300RC, Leiden, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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