Linked Life Data

19532856

Source:http://linkedlifedata.com/resource/pubmed/id/19532856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2009-6-17
pubmed:abstractText
The emergence and increasing prevalence of multi-drug resistance bacterial strains represents a clear and present danger to the standard of human healthcare as we know it. The systematic study of modulating biological systems using small molecules (so-called chemical genetics) offers a potentially fruitful means of discovering critically needed new antibacterial agents. Crucial to the success of this approach is the ready availability of functionally diverse small molecule collections. In this feature article we focus upon the use of a diversity-oriented synthesis (DOS) approach for the efficient generation of such compound collections, and discuss the utility of DOS for the discovery of new antibacterial agents.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1359-7345
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2446-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The discovery of antibacterial agents using diversity-oriented synthesis.
pubmed:affiliation
Department of Chemistry, University of Cambridge, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't