Linked Life Data

19531870

Source:http://linkedlifedata.com/resource/pubmed/id/19531870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-5-26
pubmed:abstractText
An ideal bone implant should facilitate the formation of a new bone layer as an osteo-integrated interface between bone and the implanted biomaterials. In the present work, the interface between carbonated hydroxyapatite (CHA) cement and bone was evaluated by interfacial bonding strength measurements and histological characterizations. CHA cement was implanted into a mongrel dog's femoral supracondylar and below the tibial plateau area, and was then tested ex vivo by, respectively, detaching and pullout experiments. Polymethylmethacrylate (PMMA) was used as a control. CHA cement could be directly injected and solidified in situ to repair bone defects. Histology results showed that CHA bonded with bone through gradual remodeling and was replaced by new bone tissue, which is an attribute for excellent biocompatibility. The interfacial bonding strength increased with implantation time. After 16 weeks implantation, the measured detaching force and the pullout force between CHA and bone were 281 +/- 16 N and 512.5 +/- 14.5 N, respectively. These values were several times higher compared to 5 days implantation. In contrast, the control showed a fibrous microstructure between PMMA and bone, and the detaching force and the pullout force decreased with implantation time. The results strongly suggest that CHA can form a better osteo-integrated interface compared to PMMA, and could be used as an ideal biomaterial for bone defect repair.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1748-605X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
045003
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Investigation of the histology and interfacial bonding between carbonated hydroxyapatite cement and bone.
pubmed:affiliation
Department of Orthopedics, General Hospital of People's Liberation Army, 28 Fuxing Road, Beijing 100853, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't