|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2009-7-1
|
|
pubmed:abstractText |
Dendritic cells localized at the adventitia-media border of the normal medium-sized arteries play a pivotal role in the initiation of giant cell arteritis (GCA). These cells express a singular surface receptor profile, including a series of Toll-like receptors (TLR). Ligands of TLR-4 promote activation and differentiation of adventitial dendritic cells and are directly implicated in the pathogenesis of GCA. We aimed to assess the potential implication of the TLR4-(+896 A/G) gene polymorphism in the susceptibility to GCA.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0315-162X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
36
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1501-6
|
|
pubmed:meshHeading |
pubmed-meshheading:19531762-Aged,
pubmed-meshheading:19531762-Aged, 80 and over,
pubmed-meshheading:19531762-Alleles,
pubmed-meshheading:19531762-Biopsy,
pubmed-meshheading:19531762-Case-Control Studies,
pubmed-meshheading:19531762-Female,
pubmed-meshheading:19531762-Genetic Predisposition to Disease,
pubmed-meshheading:19531762-Genotype,
pubmed-meshheading:19531762-Giant Cell Arteritis,
pubmed-meshheading:19531762-Humans,
pubmed-meshheading:19531762-Male,
pubmed-meshheading:19531762-Middle Aged,
pubmed-meshheading:19531762-Polymorphism, Genetic,
pubmed-meshheading:19531762-Toll-Like Receptor 4
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Association between toll-like receptor 4 gene polymorphism and biopsy-proven giant cell arteritis.
|
|
pubmed:affiliation |
Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Cientificas (CSIC), Granada, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
