Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-12-18
pubmed:abstractText
Cardiopulmonary bypass (CPB) using nonpulsatile flow (NPF) is advocated for refractory cardiac arrest. This study examined cerebral outcome after resuscitation with pulsatile flow (PF) versus NPF. Dogs arrested for 12.5 minute were reperfused with NPF (n = 11) using roller pump CPB or PF (n = 11) using mechanical biventricular cardiac massage. Pump flows were similar between groups; however early arterial pressures were greater during PF versus NPF, *p less than 0.05. Circulatory support was weaned at 60 minutes' reperfusion. Neurologic recovery of survivors (n = 16) was significantly better after PF versus NPF, *p = 0.01. The presence of brain lesions on magnetic resonance images did not significantly differ between groups at 7 days. Brain then were removed and regions examined for ischemic changes. Loss of CA1 pyramidal neurons was more severe after NPF versus PF, +p = 0.009. Ischemic changes were more frequent after NPF in the caudate nucleus (+p = 0.009) and watershed regions of the cerebral cortex (+p = 0.062), compared with PF. These results demonstrate that PF improves cerebral resuscitation when treating cardiac arrest with mechanical circulatory support (* = MANOVA with repeated measures, + = categorical data analysis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-1704174, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-1751261, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-1852068, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-1905620, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-1999938, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2117099, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2291391, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2297254, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2298837, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2382236, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2389298, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2403478, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2464145, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-2521442, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-3048894, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-3048898, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-3785619, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-3968158, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-4046623, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-4069376, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-416759, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-4555147, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-4652728, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-4763617, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-4898603, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-5691594, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-5921294, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-6360057, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-6538660, http://linkedlifedata.com/resource/pubmed/commentcorrection/1953100-7080118
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-4932
pubmed:author
pubmed:issnType
Print
pubmed:volume
214
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-88; discussion 489-90
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pulsatile reperfusion after cardiac arrest improves neurologic outcome.
pubmed:affiliation
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
pubmed:publicationType
Journal Article, Comparative Study