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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2009-7-16
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pubmed:abstractText |
Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry. The discovery of isoCA-4 with biological activities comparable to that of CA-4 represents a major progress in this field.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:AlamiMouâdM,
pubmed-author:BignonJérômeJ,
pubmed-author:BrionJean-DanielJD,
pubmed-author:De LosadaJordi RodrigoJR,
pubmed-author:DuboisJoëlleJ,
pubmed-author:HamzeAbdallahA,
pubmed-author:LiuJian-MiaoJM,
pubmed-author:MessaoudiSamirS,
pubmed-author:PeyratJean-FrançoisJF,
pubmed-author:ProvotOlivierO,
pubmed-author:ThoretSylvianeS,
pubmed-author:TréguierBretB,
pubmed-author:Wdzieczak-BakalaJoannaJ
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4538-42
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pubmed:meshHeading |
pubmed-meshheading:19530698-Antineoplastic Agents,
pubmed-meshheading:19530698-Bibenzyls,
pubmed-meshheading:19530698-Cell Line, Tumor,
pubmed-meshheading:19530698-Cell Proliferation,
pubmed-meshheading:19530698-Chlorophenols,
pubmed-meshheading:19530698-Humans,
pubmed-meshheading:19530698-Models, Molecular,
pubmed-meshheading:19530698-Molecular Conformation,
pubmed-meshheading:19530698-Peptides, Cyclic,
pubmed-meshheading:19530698-Stereoisomerism,
pubmed-meshheading:19530698-Tubulin Modulators
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pubmed:year |
2009
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pubmed:articleTitle |
Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.
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pubmed:affiliation |
Laboratoire de Chimie Therapeutique, Faculte de Pharmacie, Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Clement, Chatenay-Malabry F-92296, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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