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pubmed:abstractText |
The Pictet-Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid methyl esters with 1-(1'-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics.
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pubmed:affiliation |
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland. karola@chem.uw.edu.pl
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