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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-20
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pubmed:abstractText |
Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy. In the current study, we evaluated the effects of a combination treatment consisting of inhalation of aerosolized liposomal amphotericin B (L-AMB) with intraperitoneal administration of micafungin (MCFG) against murine invasive pulmonary aspergillosis. The combination of aerosolized L-AMB with intraperitoneal MCFG significantly improved the survival rate, and the fungal burdens and histopathology findings after this treatment were superior to those of the control and both monotherapy groups.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1098-6596
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pubmed:author |
pubmed-author:ImamuraYoshifumiY,
pubmed-author:IzumikawaKoichiK,
pubmed-author:KakeyaHiroshiH,
pubmed-author:KohnoShigeruS,
pubmed-author:KosaiKosukeK,
pubmed-author:MiharaTomoT,
pubmed-author:MiyazakiTaigaT,
pubmed-author:SaijoTomomiT,
pubmed-author:SekiMasafumiM,
pubmed-author:TakazonoTakahiroT,
pubmed-author:YamamotoYoshihiroY,
pubmed-author:YanagiharaKatsunoriK
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3508-10
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19528281-Amphotericin B,
pubmed-meshheading:19528281-Animals,
pubmed-meshheading:19528281-Antifungal Agents,
pubmed-meshheading:19528281-Drug Therapy, Combination,
pubmed-meshheading:19528281-Echinocandins,
pubmed-meshheading:19528281-Female,
pubmed-meshheading:19528281-Injections, Intraperitoneal,
pubmed-meshheading:19528281-Invasive Pulmonary Aspergillosis,
pubmed-meshheading:19528281-Lipopeptides,
pubmed-meshheading:19528281-Lung,
pubmed-meshheading:19528281-Mice,
pubmed-meshheading:19528281-Mice, Inbred ICR
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pubmed:year |
2009
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pubmed:articleTitle |
Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis.
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pubmed:affiliation |
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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