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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2009-7-15
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pubmed:abstractText |
A series of 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines 10a-z was prepared as novel 5-HT(6) ligands. The best compounds were high affinity, full agonists at 5-HT(6) receptors. Several agonists demonstrated good selectivity over other serotonergic and dopaminergic receptors. Acute administration of selective agonist 10e significantly increased extracellular GABA concentrations in rat frontal cortex. This compound also reduced adjunctive drinking behavior in the rat schedule-induced polydipsia assay, possibly predictive of efficacy in obsessive compulsive disorder and other anxiety related disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:AntaneSchuylerS,
pubmed-author:BernotasRonald CRC,
pubmed-author:BeyerChad ECE,
pubmed-author:ColeDerek CDC,
pubmed-author:CoupetJosephJ,
pubmed-author:HarrisonBoyd LBL,
pubmed-author:LenicekStevenS,
pubmed-author:LiPingP,
pubmed-author:PlattBrianB,
pubmed-author:RobichaudAlbert JAJ,
pubmed-author:Rosenzweig-LipsonSharonS,
pubmed-author:SchechterLee ELE,
pubmed-author:SecoJJ,
pubmed-author:SmithDeborahD,
pubmed-author:ZhangGuo MingGM
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5153-63
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19523834-Animals,
pubmed-meshheading:19523834-Cerebral Cortex,
pubmed-meshheading:19523834-Drinking Behavior,
pubmed-meshheading:19523834-Glutamic Acid,
pubmed-meshheading:19523834-HeLa Cells,
pubmed-meshheading:19523834-Humans,
pubmed-meshheading:19523834-Protein Binding,
pubmed-meshheading:19523834-Rats,
pubmed-meshheading:19523834-Receptors, Serotonin,
pubmed-meshheading:19523834-Serotonin Receptor Agonists,
pubmed-meshheading:19523834-gamma-Aminobutyric Acid
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pubmed:year |
2009
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pubmed:articleTitle |
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.
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pubmed:affiliation |
Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. bernotr@wyeth.com
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pubmed:publicationType |
Journal Article
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