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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-8-3
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pubmed:abstractText |
CD40 ligand (CD40LG), encoded on the X chromosome, has been reported to be overexpressed on lupus T cells. Herein, we investigated the effect of DNA demethylation on T cell CD40LG expression and the production of IgG by autologous B cells in lupus. We found normal human T cells transfected with CD40LG induced autologous B cell activation and plasma cell differentiation. Both female lupus CD4+ T cells and demethylating agents treated CD4+ T cells overexpressed CD40LG mRNA. Further, lupus T cells from both genders or demethylated CD4+ T cells from healthy women overstimulated autologous B cells, and this could be reversed with anti-CD40LG Ab in only females. We demonstrated that female lupus CD4+ T cells and demethylated CD4+ T cells express high level of CD40LG and overstimulate B cells to produce IgG. This is due to DNA demethylation and thereby reactivation of the inactive X chromosome in female.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1521-7035
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pubmed:author |
pubmed-author:FeiYipingY,
pubmed-author:JiP YPY,
pubmed-author:LeiWenzhiW,
pubmed-author:LiYapingY,
pubmed-author:LongHaiH,
pubmed-author:LuQianjinQ,
pubmed-author:LuoYongqiY,
pubmed-author:PanYujunY,
pubmed-author:QiuXiangningX,
pubmed-author:RichardsonBruceB,
pubmed-author:SawalhaAmr HAH,
pubmed-author:YuanJunJ,
pubmed-author:ZhouYingY
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pubmed:issnType |
Electronic
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-70
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19520616-Adolescent,
pubmed-meshheading:19520616-Adult,
pubmed-meshheading:19520616-Antibodies, Monoclonal,
pubmed-meshheading:19520616-Antibody Formation,
pubmed-meshheading:19520616-Antigens, CD,
pubmed-meshheading:19520616-B-Lymphocytes,
pubmed-meshheading:19520616-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19520616-CD40 Ligand,
pubmed-meshheading:19520616-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19520616-DNA Methylation,
pubmed-meshheading:19520616-Enzyme Inhibitors,
pubmed-meshheading:19520616-Female,
pubmed-meshheading:19520616-Gene Expression Regulation,
pubmed-meshheading:19520616-Humans,
pubmed-meshheading:19520616-Immunoglobulin G,
pubmed-meshheading:19520616-Lipopolysaccharides,
pubmed-meshheading:19520616-Lupus Erythematosus, Systemic,
pubmed-meshheading:19520616-Lymphocyte Activation,
pubmed-meshheading:19520616-Male,
pubmed-meshheading:19520616-Sex Characteristics,
pubmed-meshheading:19520616-T-Lymphocytes,
pubmed-meshheading:19520616-Transfection,
pubmed-meshheading:19520616-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus.
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pubmed:affiliation |
Department of Dermatology and Epigenetic Research Center, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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