Linked Life Data

19520292

Source:http://linkedlifedata.com/resource/pubmed/id/19520292

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pubmed-article:19520292pubmed:abstractTextThe purpose of this study was to determine the feasibility of radiolabeling liposomal doxorubicin (Doxil) for cancer chemoradionuclide therapy by directly loading the therapeutic radionuclide rhenium-186 ((186)Re) into the liposome interior. The pharmacokinetics, imaging and biodistribution of [(186)Re]Doxil (555 MBq/kg) and control [(186)Re]polyethylene glycol (PEG) liposomes (555 MBq/kg) were determined after intravenous administration in a head and neck cancer xenograft model in nude rats. [(186)Re]Doxil and [(186)Re]PEG liposomes were radiolabeled using [(186)Re]N,N-bis(2-mercaptoethyl)-N',N'-diethylethylenediamine. (186)Re labeling efficiency was 76.1+/-8.3% with Doxil. The in vitro serum stability of [(186)Re]Doxil at 37 degrees C was 38.06+/-12.13% at 24 h. Pharmacokinetic studies revealed that [(186)Re]Doxil had a two-phase blood clearance with half clearance times of 0.8 and 28.2 h. Images acquired over 120 h showed that [(186)Re]Doxil had slow blood clearance, low liver accumulation and increasing spleen accumulation. The biodistribution study at 120 h indicated that the percentage of injected dose (%ID) in the blood and tumor for [(186)Re]Doxil was 20-fold higher than that of [(186)Re]PEG liposomes. The %ID values in the kidney and liver were not significantly different between [(186)Re]Doxil and [(186)Re]PEG liposomes. These results suggest that the long circulation and prolonged bioavailability of [(186)Re]Doxil could potentially deliver high concentrations of both doxorubicin and (186)Re to tumor when encapsulated in the same liposome vehicle.lld:pubmed
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pubmed-article:19520292pubmed:issn1872-9614lld:pubmed
pubmed-article:19520292pubmed:authorpubmed-author:BERGS SSSlld:pubmed
pubmed-article:19520292pubmed:authorpubmed-author:PhillipsWilli...lld:pubmed
pubmed-article:19520292pubmed:authorpubmed-author:PerezRicardoR...lld:pubmed
pubmed-article:19520292pubmed:authorpubmed-author:GoinsBeth ABAlld:pubmed
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pubmed-article:19520292pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:19520292pubmed:year2009lld:pubmed
pubmed-article:19520292pubmed:articleTitle[(186)Re]Liposomal doxorubicin (Doxil): in vitro stability, pharmacokinetics, imaging and biodistribution in a head and neck squamous cell carcinoma xenograft model.lld:pubmed
pubmed-article:19520292pubmed:affiliationDepartment of Radiology, University of Texas Health Science Center, San Antonio, 78229-3900, USA.lld:pubmed
pubmed-article:19520292pubmed:publicationTypeJournal Articlelld:pubmed
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