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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-6-12
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pubmed:abstractText |
The purpose of this study was to determine the feasibility of radiolabeling liposomal doxorubicin (Doxil) for cancer chemoradionuclide therapy by directly loading the therapeutic radionuclide rhenium-186 ((186)Re) into the liposome interior. The pharmacokinetics, imaging and biodistribution of [(186)Re]Doxil (555 MBq/kg) and control [(186)Re]polyethylene glycol (PEG) liposomes (555 MBq/kg) were determined after intravenous administration in a head and neck cancer xenograft model in nude rats. [(186)Re]Doxil and [(186)Re]PEG liposomes were radiolabeled using [(186)Re]N,N-bis(2-mercaptoethyl)-N',N'-diethylethylenediamine. (186)Re labeling efficiency was 76.1+/-8.3% with Doxil. The in vitro serum stability of [(186)Re]Doxil at 37 degrees C was 38.06+/-12.13% at 24 h. Pharmacokinetic studies revealed that [(186)Re]Doxil had a two-phase blood clearance with half clearance times of 0.8 and 28.2 h. Images acquired over 120 h showed that [(186)Re]Doxil had slow blood clearance, low liver accumulation and increasing spleen accumulation. The biodistribution study at 120 h indicated that the percentage of injected dose (%ID) in the blood and tumor for [(186)Re]Doxil was 20-fold higher than that of [(186)Re]PEG liposomes. The %ID values in the kidney and liver were not significantly different between [(186)Re]Doxil and [(186)Re]PEG liposomes. These results suggest that the long circulation and prolonged bioavailability of [(186)Re]Doxil could potentially deliver high concentrations of both doxorubicin and (186)Re to tumor when encapsulated in the same liposome vehicle.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-10912572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11062762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11156255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11259838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11337529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11405181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11454922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11597379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-11668491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-12057136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-12593943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-12739982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-14610219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-14660726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-15717745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-15850546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-16221908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-16398614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-1670497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-16818648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-16952872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-16979448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-17141073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-17168775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-17499731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-1751529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-17695506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-17827462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-18559620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-18591980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-18686132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-18686134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-18703613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-19026950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-2544306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-2778836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-3413128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-6892980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-8321835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-8417385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-8475412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-8912370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19520292-9473271
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1872-9614
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
515-24
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19520292-Animals,
pubmed-meshheading:19520292-Autoradiography,
pubmed-meshheading:19520292-Carcinoma, Squamous Cell,
pubmed-meshheading:19520292-Disease Models, Animal,
pubmed-meshheading:19520292-Doxorubicin,
pubmed-meshheading:19520292-Drug Stability,
pubmed-meshheading:19520292-Feasibility Studies,
pubmed-meshheading:19520292-Head and Neck Neoplasms,
pubmed-meshheading:19520292-Humans,
pubmed-meshheading:19520292-Male,
pubmed-meshheading:19520292-Radioisotopes,
pubmed-meshheading:19520292-Rats,
pubmed-meshheading:19520292-Rhenium,
pubmed-meshheading:19520292-Staining and Labeling,
pubmed-meshheading:19520292-Tissue Distribution,
pubmed-meshheading:19520292-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:19520292-Tomography, X-Ray Computed,
pubmed-meshheading:19520292-Transplantation, Heterologous
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pubmed:year |
2009
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pubmed:articleTitle |
[(186)Re]Liposomal doxorubicin (Doxil): in vitro stability, pharmacokinetics, imaging and biodistribution in a head and neck squamous cell carcinoma xenograft model.
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pubmed:affiliation |
Department of Radiology, University of Texas Health Science Center, San Antonio, 78229-3900, USA.
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pubmed:publicationType |
Journal Article
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